Geochronology, petrology and geochemistry were performed systematically on the late Permian intermediary-mafic intrusions in Fumin, Yunnan province. On the basis of petrography and major elements characteristics, mafic intrusions belong to diabase in lithology (high-Ti type), while Pangxiejing dyke is alkaline monzonlite. Both display an enrichment of LREE, LILE, HFSE, and have Ocean island basalts (OIB) features. The Sr-Nd isotopic compositions are similar, with mafic intrusions:(87Sr/86Sr)i=0.70565~0.70626, εNd(t)=-0.06~+0.49 and intermediary intrusions:(87Sr/86Sr)i=0.70564~0.70567, εNd(t)=-0.32~+0.41. The result of isotope geochronology of mafic intrusions is 256.7±4.3Ma by LA-ICP-MS, which indicates that the intermediary-mafic intrusions were formed in the late stage of large-scale magmatism of Emeishan large igneous province. The intermediary-mafic intrusions appear to be related to the high-Ti basaltic lavas principally by continuous evolution. The primitive magma was derived from mantle plume confined within the garnet stability field and a relatively low degree of melting. Rough correlations of isotope ratios with ratios of alteration-resistant highly incompatible elements (e.g., Nb/U) suggest no crust contamination in the formation of mafic intrusions, while minor amounts of contamination with monzonlite dyke. The discovery of the late Permian intermediary-mafic intrusions in Fumin would shed light on the debate of the “Daly gap” in the bimodal volcanic intrusions, and provide the key evidence for the origin model of silicic magma by the differentiation of mantle-derived basaltic intrusions.