The middle Grandise in Tibet is the important component of the Gangdese metallogenic belt in the Qinghai-Tibet Platean, which was studied geologically in obviously lower degree than the southeastern Gangdese. Influenced from both the southward subduction of Bang Co-Nujiang Tethyan Ocena crust and northward subduction of Yarlung Zangbo neo-Tethyan Ocean, Meso-Cenozoic magmnatic activities extremely favourable mineralizing conditions and great potentials of mineral resources. Prospecting and Metallogenic Regularities of Iron and Copper is analyzed by using the Metallogenic Series .On the bases of the features of deposits (ore occurrences) found newly and the space-time distribution of various types of mineralization in the middle Gangdese, five Ⅳ-level metallogenic subzones , i. e. Ⅰ-Dongcuo-Nima copper-antimony polymetallic metallogenic belt,Ⅱ-Jiangma-Wenbu iron copper metallogenic belt,Ⅲ-Daxiong-Jiagu copper iron metallogenic belt,Ⅳ-Ronggeer-Nixiong iron-copper ore occurrences and Ⅴ-Jiesacuo-Chazi copper polymetallic、Uranium thorium metallogenic belt can be divided; and twenty-two Ⅴ-level prospects was redivided into.Two metallogenic series can be defined into,i. e. the metallogenic series of iron deposit involved in the intermediate-acid intrusive rock of Yanshan Period and the metallogenic series of copper polymetallic deposit associated with porphyry of Himalayan period ; and six metallogenic sub-series have been preliminarily distinguished in the Middle Gangdese.