Zircon LA-ICPMS U-Pb and Molybdenite Re-Os Dating was conducted for the Lurige porphyry Mo-Cu deposit, which is located in the northern portion of Sanjiang polymetallic Ore belt, sourthern Qinghai. The results give two average weighted LA-ICP-MS 206Pb/238U ages of 62.1±0.4Ma and 61.7±0.3Ma for biotite granitic porphyry and fine-grained granitic porphyry. All the zircons tested show the characteristics co magmatic origin. The zircon U-Pb isotopic age may represent the crystallization age of porphyry. The 187Re and 187Os contents of five molybdenite samples from the Lurige deposit determined by ICP-MS show that the Re-Os model age ranges between 59.2～62.8Ma, with an average mean age of 60.7±1.5 Ma. The zircon LA-ICP-MS U-Pb age is in consistent with and molybdenite Re-Os dating, and both may constraint the magmatic activity and mineralization with early Paleocene. Mineralization of the Lurige deposit is about 20 Ma earlier than porphyry deposits in the northern Sanjiang, which indicates that at least two large-scale porphyry mineralization occurred in northern Sanjiang ore belt from Paleocene to oligocene. As the earliest Cenozoic magmatic mineralization in the Sanjiang metallogenic belt, the Lurige porphyry molybdenite-copper deposit is worth further studying.