Isotope geochronology is a newly developed science which combines geoscience, Physics, Chemistry and technical sciences, and it is a young and energetic branch of the earth system science. Based on the decay of radioactive isotopes, this science can determine the formation age of geological body and the age of geological events, aiming to study the formation history and evolution of earth and planetary materials. This paper presents brief introduction and summary of relative high-precise isotope dating methods in aspects of theory、experiment techniques、application scope、precautions for use, expecting to provide a useful reference to geologist. Involved isotope dating methods are U-Pb method、Ar-Ar method、 Rb-Sr method、Sm-Nd method、Re-Os method and（U-Th）/He method. （1）U-Pb method: It is one of the earliest radioactive methods for geological age determination as well as the most important isotope dating method in China so far. In the past 10 years, the introduction of insitu zircon U-Pb dating technique has played a significant role in promoting geological research in China, and its application is expanding. （2）Ar-Ar method: Ar-Ar dating has become one of the most important methods of isotope geochronology. The characteristics of this method are as follows: ① wide time-domain measurements, the oldest age is 3.8Ga (the age of lunar rocks), millennium age can be measured for the youngest age (eruption age of Mount Vesuvius, Italy); ② wide range of measurement object, in principle, all the k-bearing minerals and rocks can be used as Ar-Ar isotopic dating, even there are reports on successful determination of Ar-Ar ages from non-potassium minerals such as quartz、sphalerite which contain trace amounts of kainitite inclusion; ③Unique step heating technique and the management of Ar isotope correlation diagram of internal components can not only obtain high-precision age but unfold multi-stage geological evolution of the object; ④Joining with laser technique, it can be used to determine microzonation Ar-Ar age by search the minerals to be tested in polished section, so that we can obtain the priciest time information of the metamorphic rock P-T-t research; ⑤ wide application area, it is used in almost all the branches of geology; ⑥ the most important technique of deposit chronology; ⑦ the backbone technique of isotope thermochronology. Ar-Ar dating has its limitations: Firstly, the complex analysis leads to high cost and long cycle. Secondly, the accuracy of the determination of the neutron parameters directly affects the accuracy of dating samples. Nuclear recoil effect can result in high Ar-Ar age of very fine particles of clay minerals. As samples of Early Proterozoic and Archean metamorphic rocks, there may be natural K and Ar diffusion or later metamorphism, deformation and other disturbance, which will make it difficult for us to determine the age of early metamorphic events. （3）Rb-Sr method: It is a broadly applicated method. We can determine the isotope geological ages of intrusive rocks、volcanic rocks、metamorphic rocks and certain sedimentary rocks by using isochron technique. When determining the age of intermediate and acid intrusive rocks and volcanic rocks by using Rb-Sr isotopic system, if the rocks cooled rapidly, both the whole rock isochron and mineral isochron age may be the formation ages of the rocks. For metamorphic rocks, Rb-Sr isochron age generally represent the Sr isotope homogenization time when the latest strong thermal event happened. For sedimentary rocks, we can determine the authigenic mineral diagenesis age using Rb-Sr dating. The metal deposits, we can determine the formation ages of deposits using inclusion Rb-Sr isochron. Through Rb-Sr mineral dating to determine the formation of faults and ductile shear zone, we can limit the tectonic formation time. The biggest drawback of Rb-Sr dating is that, we may get wrong age due to the mobility of Rb which will result in an open system. In addition, we often face false isochrons problems. （4）Sm-Nd method: For Sm-Nd system is good at preservation and alteration and metamorphism resistance, ages from Sm-Nd dating can represent the original time when primary rocks formed and reflect the characteristics of diagenesis source material. For basic rocks、 ultrabasic rocks and for ancient rocks of Archean, Sm-Nd isochron dating method is a good method. Sm-Nd model age represent the time when the crustal rocks differentiated from CHUR mantle, using model ages of clastic sedimentary rocks, we can identify the source, the background of tectonic, the mean crustal residence age, and the formation and evolution history of crust. The disadvantage is the similarity of Sm, Nd geochemical properties, it will be difficult to separate from each other in the geologic process, and will result in narrow range of Sm, Nd ratio, which will make the Sm-Nd isochron dating problematic and even can not give reliable age. （5） Re-Os method: Re-Os isotope dating is the only mature method to determine mineralization ages of metal deposits directly. However, there are many problems in experiment techniques and applications: ① In recent years, some scientists find that the Re-Os ages of molybdenite in some metal deposits were higher than the ages of ore-bearing rocks, the reasons are unclear; ② the amount of Re in most sulfide mineral including pyrite is significantly low, and contains certain amount of common Os, this requires very low background in the process of chemical preparation of samples, which makes it difficult for general laboratory to achieve, and the common Os is difficult to deduct; ③ sometimes, post hydrothermal activities may reset Os isotope, therefore, the closure temperature and influencting factors of the metal sulfide Re-Os isotope system is a pressing problem to be solved. （6） (U-Th) / He method: The advantage of (U-Th) / He isotope system is that its closure temperature is the lowest among the existing isotopic systems, and it can record temperature information and the time when geologic body went through a lower temperature process. The method also has considerable application in the deposits chronology. The disadvantage is that as the closure temperature is very low, we should pay special attention to the cooling rate and effects of re-heating in geological dating.