The genesis of Fe-Cu-Au mineralization in Luzong basin, Anhui province, is related to the Yanshan stage’s magmatic of time, space and formation. By researching on the age of Zircon U-Pb and its constraint on the formation time of the mineralization, the article shows that the formation of mineralization of ore-bearing magmatic rocks in Luzong basin happened in 135~126Ma. And the geodynamic background of the mineralization corresponds with the two geological occurrences happened in Mesozoic in eastern China, which are the great break of tectonic system and the lithosphere large-scale detachment.