Xiejiagou gold deposit, newly descovered in the Eastern Shandong Province, is a large-size gold deposit. The paper researches REE geochemistry characteristics of biotite granites, dikes and ore, considering granites, intermediate-basic dikes and mineralizing fluid have the consanguinity and inheritance; The rock and ore-forming meterials mainly originated from deep crust-mantle transitional zone; While the mineralization of Xiejiagou gold deposit is controlled by the mesozic large-scale crust-mantle interaction in the Eastern part of North China.