This paper mainly studies the Cenozoic uplifting history of the West Shandong Rise and the subsidence of the Jiyang Depression in order to understand the uplifting history of the West Shandong Rise (WSR), the relationship between the WSR and the Jiyang Depression, further better our insights into the Bohai Bay Basin. Our AFT analysis and AFT t-T model indicates that there were three relatively rapid stages for uplifting of the West Shandong Rise: 62~53 Ma, 44~37 Ma and 23~20 Ma. Meanwhile, two rapid subsidence with big a big magnitude of subsidence at 65~46 Ma and 46~38 Ma, and one uplifting at 23 Ma also took place in the Jiyang Depression. Comparison study shows that the uplifting of the West Shandong Rise at Cenozoic coupled well with the subsidence of the Jiyang Depression. Furthermore, the uplifting events not only control the formation of hydrocarbon's mother rock, and the time, distribution and migration of oil-gas, but also provide a reservoir space for the oil-gas in the buried hills. Our research also suggests that the uplift-depression coupling events are part of the couplings between the Bohai Bay Basin and its peripheral mountains.