Many geometric and kinematic evidences show that the Yi-Shu Fault Zone had experienced compressive sinistral strike-slipping movement between the late Cretaceous and early Tertiary. Fission track ages of samples, including fault gouge and cataclastic rock, collected from 4 faults of the Yi-Shu Fault Zone are much younger than un-deformed rocks collected around the faults, because fission track had experienced total annealing during the movement of the faults. Reverse modeling of fission track data with correlative software show that all samples had experienced fast cooling episodes before 70~60 Ma and since about 10 Ma. Analyzing all information, a conclusion can be drawn that the time of large-scale sinistral strike-slip movement was in 70~60 Ma. The regional fast uplift episode of about 10 Ma maybe relate to fast extension of the Tibetan Plateau at the same time.