Miocene adakite porphyries are widely distributed in the southern margin of Lhasa terrane, but there are obvious differences in the composition of ore-forming elements and the scale of mineralization. In order to better understand the constraints of different mineralization of Miocene porphyries in the southern margin of Lhasa terrane, this paper selects the ore-bearing porphyries of Jiama Cu deposit and Bangpu Mo deposit, to carry out TIMA scanning and electron probe studies of single melt inclusions in quartz phenocrysts of the different porphyries. The results show that the melt inclusions of Jiama and Bangpu are mainly crystalline whose crystalline minerals mainly include quartz, albite, orthoclase, plagioclase and mica. There is a significant negative correlation between SiO2 and K2O in the melt inclusions of Jiama and Bangpu, which all belong to the?high-K calc-alkaline to shoshonite series. The Jiama ore bearing porphyry has lower Cl (0-0.03 wt%) and higher H2O (1.12-4.35 wt%) contents compared to Bangpu porphyry. Research has shown that the injection of ultrapotassium magma and strong crystallization differentiation of potassium feldspar play an important role in the formation of porphyry deposits of collisional environment. In addition, the content of volatile matter (including H2O, Cl, etc.) plays a significant role in the differnent metallogenensis.