The Jiaodong Gold Mine Cluster is a world-famous gold resource base. By the end of 2020, the total amount of gold resources identified reached 5400 tons. The Mesozoic granites in the Jiaodong area are widely distributed with many rock types and closely related to gold deposits. According to the division method of age+magmatic event+lithology, the Mesozoic granites widely distributed in Jiaodong region are divided into the Late Jurassic Linglong stage, the early Early Cretaceous Guojialing stage, the Late Early Cretaceous Weideshan stage and the Laoshan stage. The relationship between the above four stages of granites and gold deposits, including spatial distribution, source of ore-forming materials, and age of formation are studied. The sulfur isotope of gold ore is similar to the Linglong granite and the Guojialing granite, especially overlapping with the Linglong granite. The lead of gold ore is mainly the reactivated lower crust lead, i.e. the Precambrian crystalline basement lead, with the addition of mantle-derived lead. The data of Sr-Nd allotrope of gold ore mostly overlaps with the Precambrian metamorphic basement, the Linglong granite, the Guojialing granite and the Mesozoic vein rock, suggesting that Sr-Nd mainly comes from the crustal source area. The Au elements of the Jiaodong gold deposit may come from the Jiaodong magmatic rock group, the Neo-Archean TTG rocks, the Linglong granite and the Guojialing granite, mainly from the lower crust (initially the Precambrian crystalline basement of the North China plate and the Yangtze plate), with the addition of crust-mantle interaction mantle materials. Spatially, 88% of the gold resources are hosted in the Linglong granite, 7% in the Guojialing granite, and only 0.1% in the Weideshan and the Laoshan granites. In terms of time, the formation time of granite in Linglong stage of Late Jurassic, Guojialing stage of Early Cretaceous, Weideshan stage and Laoshan stage of Late Cretaceous are 166～146 Ma, 135～123 Ma, 123～110 Ma, 118～108 Ma respectively, and the age of gold deposit is 162～146 Ma, 133～120 Ma, 120～105 Ma, 110～105 Ma, which have good corresponding relationship. The mineralization events are generally synchronous or slightly lagged behind the homologous magmatic activities, i.e. the 162～146 Ma mineralization period corresponds to the emplacement event of the Linglong period remelted granite, the 133～120 Ma mineralization period corresponds to the emplacement event of the Guojialing period granite, the 120～105 Ma mineralization period corresponds to the Weideshan period and the 110～105 Ma mineralization period corresponds to the Laoshan period granite emplacement event. Therefore, the Jiaodong gold mineralization period can be divided into the Linglong gold mineralization period, the Guojialing gold mineralization period, the Weideshan gold and polymetallic mineralization period and the Laoshan molybdenum mineralization alteration period.