Jiaodong is one of the three gold provinces with proven gold reserves of more than 5000 tons. With the continuously increasing degree of geological exploration, there are fewer and fewer surface and shallow deposits, and the deep and covered areas have become the key focus of ore prospecting in this area. The fine-grained soil prospecting method, a deep-penetrating geochemistry method that can recognize the anomaly information coming from the deep orebodies, has been successfully used for mineral exploration in the covered areas. In this paper, the fine-grained soil prospecting method was carried out in the Qujia concealed gold deposit and its periphery area which is located in the Laizhou City, Shandong Province and covered by alluvial soil. The results show that: ① the content of Au is significantly higher than that of Chinese, Shandong Province, and Yantai City soils, and the regional concentration coefficient is as high as 2.88, indicating that Au is highly enriched in the study area; ② the range of Au and Ag geochemical anomalies has a good corresponding relationship with the known hidden orebodies, which can confirm each other, and have an inheritance relationship with the geochemical information of the primary halo of the borehole. A potential genesis mechanism of the anomalies is as follows: the deep ore-forming materials migrate to the surface under the action of multi-agent relay in the form of nanoparticles with gas-like properties along macro-fractures such as faults and stratum contact surfaces and micro fractures in surrounding rocks, and are captured by surface fine-grained soil to form mineralization anomalies. Satisfactory results have been obtained in the validity experiments of fine-grained soil prospecting method, which can be applied to geochemical exploration in the alluvium-covered area of Jiaodong.