The Tugerming anticline in the eastern Kuqa depression has experienced multi-stage tectonic deformation and fault activity, with poor seismic data quality and complicated distribution of oil, gas and water. The structural analytical rationality directly affects the understanding of the structural kinematic process, dynamic mechanism and hydrocarbon accumulation law in the study area. Based on the field investigations, boreholes and seismic data, this paper explains the structure of the Tugerming anticline in the eastern Kuqa depression, and restores the tectonic evolution of the study area by using the principle of balanced profile restoration. On this basis, the tectonic controlling effect of reservoir is discussed and the favorable exploration areas are pointed out. The results show that the Tuziluoke fault and Tugerming fault are mainly developed in the study area. The Tuziluoke fault mainly started to be active in the deposition period of Kuqa Formation, and the activity intensity is large, which controls the huge thickness of growth strata in forelimb and the formation of the Tugerming anticline. The Tugerming fault has been active since the end of Jurassic and controlled the formation of paleo-uplift. In plane, the study area can be divided into four zones from south to north: deep sag area, south slope area, middle anticline area and north slope area. Tectonic evolution obviously controls the burial evolution process, reservoir physical properties and preservation conditions of cap rocks in different areas, the Jurassic favorable exploration direction mainly include: local structural high position of anticlinal slope, structure-lithologic trap in the lower part of the slope zone of anticline′s south and north limb, and deep structure-lithologic trap in the footwall of fault.