A skarn-type Fe-Cu-Pb-Zn polymetallic mineralization was developed in the northern margin of Gangdise, and the Lietinggang-Leqingla deposit is the most representative deposit in this zone because it contains Fe-Cu-Pb-Zn minerals. The Fe-Cu ore body is located in the Lietinggang ore block and in the eastern Leqingla ore block, while Pb-Zn orebodies occur in the western part of the Leqingla ore block. The Jubuzhari complex pluton related to mineralization locates in the southeast of mining area and occurs as large batholith. The zircon U-Pb age of granodiorite-porphyry from the Lietinggang Fe-Cu-(Mo) deposit（62.85±0.58）Ma (n=20，MSWD=1.05), indicating that the pluton was the product of the main collision at early period of India-Asia continental collision orogeny. Petrogeochemistry shows the granodiorite-porphyry belongs to High-K, calc-alkaline and from metaluminous to peraluminous rocks. These rocks are enriched in LILE (Rb, Ba, Th, U and Pb) and depleted in HFSE (Nb, Ta, Ti, P) and Sr, and are enriched in LREE and depleted in HREE, with the ∑REE of 173.23～208.98×106 and (La/Yb)N values between 5.71～6.24 and medium δEu values (0.45～0.54), suggesting the geochemical characteristics of arc-volcanic rocks. The average temperature of zircon crystallization 693℃ and the pluton has low average of oxygen fugacity (average -8.63), indicating that the magma had experienced melting process under the condition of water nearly saturated. The granodiorite-porphyry has 176Hf/177Hf of 0.282557～0.282927, with εHf(t) of -6.25～6.79 and model age of crust TDMC/Hf from 696 Ma to 1522 Ma, suggesting that the magmatic source area of metallogenic pluton is characterized with mantle-derived magma hybrid shell source magma, which is also the main factor why it formed skarn type Fe-Cu-Pb-Zn polymetallic mineralization. Combining previous results and this study, we establish the mineralization process of Fe-Cu-Pb-Zn polymetallic mineralization in the northern Gangdise as follows: In the early main collisional period of India-Asia continental collision orogeny, subduction and revolution of the Neo Tethys oceanic crust resulted in the upwelling of asthenosphere mantle and then triggered partial melting of mantle wedge area; mantle-derived magma came into being after MASH process, and mixed crustal source magma. Respective upwelling of mantle-derived magma and crustal source magma and interaction with carbonate rock resulted in the formation of skarn type Fe-Cu and skarn type Pb-Zn mineralization in the mining area, but when uprising of mixing crust-mantle magma and interaction with carbonate rock was responsible for the formation of skarn type Fe-Cu-Pb-Zn.