The Malayer-Esfahan carbonate-hosted Pb-Zn metallogenic belt, located in the Sanandaj-Sirjan Zone (SSZ) which is the interior of Zagros collisonal orogen, is the biggest reservoir of Pb and Zn metals in Iran for the abundant carbonate-hosted Pb-Zn deposits forming in it. By comprehensive analysis, the authors pointed out that the carbonate-hosted Pb-Zn deposits in the Malayer-Esfahan belt deposited in early Paleogene when the Arabian plate was colliding with the Eurasia plate and these deposits had closed relationship with the dextral transpression structures (e.g. Thrust faults, slip faults and strike-slip pull apart basins). Ore bodies in different deposits are hosted in the lower Craterous carbonate hosts in the hanging wall or the foot wall of the regional thrust faults, they are controlled by the secondary faults and facies transitions related with the regional thrust faults, and they are strata-bound overall. The metals have Pb+Zn associations in most of the deposits, though minor Cu occurs in individual deposit. Sphalerite, galena, pyrite and minor chalcopyrite and tetrahedrite are the sulfide assemblages, and quartz, dolomite, calcite and barite are the non-sulfide assemblages. They occur in veins or hydrothermal replacements. Vein, dissemination and massive are the main ore structures. Strong silicifation and dolomitization are the main alternation. The fluid inclusions in the hydrothermal minerals are just two-phase ones with liquid and vapor. The homogenization temperatures of them are between 90℃ and 257℃, and the salinities of them are between 0% NaCl eq. and 24% NaCl eq., both of which indicate that a fluid source of basional brines with middle to low temperature and high salinity and another fluid source with middle to low temperature and middle to low salinity. The sulfur isotopic compositions in different deposits are different. The data of sulfur isotopes of sulfide in Irankuh deposit are negative (-10‰~-3‰), of barite are positive (14‰~19‰) and of sulfide in Emarat deposit are also positive (2‰~15‰). The characteristics of these sulfur isotopes indicate the bacterial sulfate reduction and the thermal sulfate reduction produced the reduced sulfur for the sulfide in which the sulfate may mainly come from the dissolved marine sulfate in the connate water of the host carbonate rocks. The lead isotopic compositions of different deposits are similar (206Pb/204Pb between 18.389 and 18.471，207Pb/204Pb between 15.628 and 15.659 and 208Pb/204Pb between 38.470 and 38.650）, which indicate the metals may come from the whole upper crust strata in the region. These carbonate-hosted Pb-Zn deposits in the Malayer- Esfahan metallogenic belt are epigenetic, have no relationship with the igneous activities, and could be classified into Mississippi Valley Type (MVT) Pb-Zn deposit in the word. However, these deposits are forming in the interior of collisional orogen, controlled by the regional transpression structures, and with abundant quartz in their assemblages, all of which characteristics can not be involved in the classical MVT deposit models in the world. So, the authors tend to call them as MVT-like Pb-Zn deposits. Similar to the ore forming processes in Sanjiang′belt which is the eastern neighbor of the Malayer-Esfahan metallogenic belt, the ore forming models of these MVT-like deposits can be explained as follows: Oblique colliding, transpression structures forming and basional brines infiltrating lead to the regional fluid gathering and trapping; organic and bacteria preparation lead to the sulfate reduction and the reduced sulfur forming; stress relaxing leads to the fluid excretion; and the fluids mixing leads to the sulfide precipitation. The abundant igneous rocks forming during the seduction stage of the Arabian plate in the SSZ and the quick descending of the fluid temperature lead to the quartz-rich assemblages' occuring.