Luzong basin located in the Middle Lower Yangtze River metallogenic belt is a Mesozoic terrestrial volcanic basin. Tectonically, Luzong basin is located among the Yangtze Plate, North China Plate and Dabie Orogeny. The volcanic rocks and synchronous intrusions occur widely in the basin, including four groups of volcanic rocks, such as Longmengyuan Group, Zhuanqiao Group, Shuangmiao Group and Fushan Group. The mineralization in the basin is of various series, including the lead zinc deposits related with Longmengyuan Group and the porphyrite type iron deposits related with Zhuanqiao Group. Recently, the researches begin to focus on the iron oxide copper uranium mineralization with syenite. Based on the study of Makou iron deposit, the uranium mineralization in the ZK01 drilling and the uranium deposits around Huangmeijian intrusion, we systematically conclude the geological characteristics and the genesis of the iron oxide copper uranium mineralization with syenite in Luzong region. The iron dioxide copper uranium mineralization occurred in the inner syenite intrusions and the contact zone, which has genetic relationship with the Cretaceous magmatism. According to the tectonic background and geochemical characteristics, the iron dioxide copper uranium mineralization in Luzong basin can be classified into two types, including iron dioxide copper uranium mineralization related with the alkaline syenite and iron dioxide copper mineralization related with A type granite. The iron dioxide copper uranium mineralization related with the alkaline syenite locates in the inner Luzong basin, whereas iron dioxide copper mineralization related with A type granite locates at the southeast boundary of Luzong basin. The age of iron dioxide copper uranium mineralization ranges from 130Ma to 110Ma when the region is in extensional setting. The mineralization similar with the IOCG type deposits probably represents the latest stage of mineralization in Luzong region and middle lower reachers of Yangtze River metallogenic belt.