The problems of minerals for dating and methods of U-Pb dating about U-Pb isotope geochronology of the Bayan Obo ore deposit are discussed based maily on our studies, combined with references recently reported. The potential prospects of U-Pb dating are studied for applying in geological research of the Bayan Obo ore deposit. The researches show that the different minerals for dating and different methods of U-Pb dating have different characteristics and limitations. It is very important to select minerals for dating and methods of U-Pb dating according to the mineral content, grain size, age range, U-Pb content and dating precision requirement of the samples to get relatively ideal results.