The genesis of mineral deposit is not only the main factor on decision of Pb-Zn deposit characteristics, and also the evidence to divide the Pb-Zn exploration types and to confirm the exploratory grids degree scientifically. This article analyze the genesis of mineral deposit on influence to decision of exploration types， and adding the genesis element to decision of exploration types in Pb-Zn deposit， Meanwhile setting the genesis element a value to ensure the new exploration types. After that， selecting 22 deposit cases in Hunan Province to verify the new exploration types， and finding the exploration type of 4 deposits had changed， including TaoLing、DongJiaHe、DiLu and YeJiWei Pb-Zn deposits， and the new one is more fit to reality.