The Lunpola, Silin Co and Nima basins formed in the Paleogene along the LunpolaSilin CoNima depression in central Tibetan Plateau. The sedimentary depression trending in eastwest is as long as 250km and as wide as 30~50km. Paleogenelacustrine, fluvial and alluvial sedimentary rocks as thick as 5~6km formed in the depression, including conglomerate, sandstone, mudstone and marl of the PaleoceneEocene Niubao Formation, and mudstone, shale and siltstone intercalated with oil shale of the Oligocene Dingqinghu Formation covered unconformable by the Neogene lacustrine deposits. The NimaSilin Co thrust formed in the southern depression, the Saibu CoZajiaZangbu thrust formed in the northern depression and thinskinned thrust formed in the northern Lunpola Basin, accompanied by folding deformation. Multiple imbricate thrust occurred in deep crust along the depression. Southward thrust in the southern Qiangtang Block and northward thrust in the northern Lhasa Block result in spatial change of crust thickness across the Paleogene sedimentary depression.Such collisional thrust at different depthes caused shortening and thickening of crust, and differential uplift of the thickening crust coupled with density variation evidently controlled the Paleogene depression and basin evolution according to seismic reflection profiling and the Airy balance modeling. Paleogene sedimentary records for depression in the Silin Co basin and its adjacent areas are significant for better understanding crust thickening and uplift process of the central Tibetan Plateau.