The Middle Lower Yangtze River metallogenic belt is well known for its endowment of Cu- Au- S- Fe polymetallic deposit, and the main deposit types contain skarn, porphyry, hydrothermal types. Spatially and temporally, the important deposits are not distributed evenly in the belt. Spatial and temporal distribution of mineral resources is uneven. Some minerals and associated ores formed at specific periods, with 99 % of Fe, Cu, Audeposits and all Pb, Zn and Tl deposits confined in late Yanshanian. Geological structure of the belt is characterized by multiple layers, block and cubic shapes. Several lithospheric faults divide the whole district into some faulting blocks, each of which exhibits distinct geological features and different evolutionary history and different tectonic magma activity, leading to different metallogenic styles, associated mineral resources and unevenly distributed metals. The intersections of principle faults and paralleled base fault formed several centers of magma mineralization activities, resulting in the formation of several ore clusters along the Yangtze River Valley. The leading controlling factor is tectonic magmatism whereas strata is another ore control factor as a favorable host rocks and locations. Particularly, some layers restricted by lithofacies and paleogeography, and favorable sedimentary facies play more important role in ore formation. Five prospective districts were delineated in the belt as the candidate national exploration areas and their resources potential were analyzed based on regional metallogenic law, new exploration achievement and the national mineral assessment project.