Due to decreasing of outcrop, and great difficulty in recognizing potential deposits, metallogenic prognosis, as a prophase work for prospecting, has been paid more attention by geologists around the world. Geologists have been searching for effective methods of prediction. This work took the YuannanSimiao area, Yunnan province as an example. Based on multifactorial analysis on metallogenic background (scale 1/200000), multisources data of geological, geophysical, geochemical and remote sensing, interpretation features were used to predict potenical economic deposits. Combined with field investigation and analysis indoors, this study defined geological variations and their properties. Because all known deposits, big or small, all fall within the target area, we can conclude that the multiinformation metallogenic prognosis method is reasonable and reliable. Field investigation also confirmed that the volcanic belt south the Lancangjiang river has a good prospecting prospect and potentiality. Prognosis map of prospecting targets in this paper will have a guiding significance to next plan of exploration.