The paper mainly focuses on the temporal and spatial distributions of 29 typical CuMoWSn deposits in South China, and the ages of related intrusive granitic rocks, and discusses the geochemical features of granitic rocks associated with various metallogenic types, such as SiO2 content, Fe2O3/FeO ratios, and Rb/Sr ratios. This study shows that 10 typical copper deposits in South China occurred mainly at 180~170Ma, 160~150Ma and 105~90Ma., and are associated with syntexis granites (I type), whereas WSn are associated with both syntexis (I type) and transformed granite rocks(S type). Copper mineralization occurred at three episodes, namely, 180~170Ma, 160~150Ma and 150~90Ma. Tungsten was mineralized dominantly at 170~130Ma, WSn deposit at 170~130Ma and 120~110Ma, and tin deposits at 170~150Ma, 130~110Ma and 100~90Ma, respectively. The granites related to CuMoWSn mineralization show different geochemical characteristics. For example, SiO2 contents increase, oxidation state decrease, redox state increase gradually and higher fractionation occurs from Cu (Mo) deposits to SnW deposits. The granites related to Cu(Mo)(Au) deposits contain less SiO2 (60.3%~68.1%)，high oxidization (Fe2O3/FeO=0.31~1.81), less fractionated (Rb/Sr=0.05~3.3) intrusions. In contrast, Cu(Pb)(Zn) deposits have a high content of SiO2(73.3%~75.2%) and fractionated (Rb/Sr=10.8~57.8) with similar oxidation (Fe2O3/FeO=0.68~1.74) intrusions. Mobearing deposits have a wide range of SiO2 (67.3%~76.2%), lowest fractionated (Rb/Sr=0.6~9.29), and low oxidation (Fe2O3/FeO=0.29~0.92) intrusions. The granites related to W deposits are associated with fractionated intrusion (Rb/Sr=21.9~61.7) of intermediate oxidation state (Fe2O3/FeO=0.19~0.76) and higher SiO2 (69.9%~80.1%). However, the WSn deposits is related to the intrusion, highly fractionated (Rb/Sr=10.8~139) and low reduced (Fe2O3/FeO=0.08~0.59), with SiO2 content from 74.8% to 78.7%; whereas the granitic rocks hosting Sn mineralization have a wide range of SiO2 (64.8%~76.9%), are highly fractionated (Rb/Sr=1~530) and reduced (Fe2O3/FeO=0.01~0.58). Combined with distribution of granitic rocks and characteristics of basinal ridges in South China, this study proposed that the CuMoWSn mineralization in South China was the result of oceanic plates in several stages and/or multistage ridge subduction, i.e., Early Jurassic Farallon Izanagi active ridge subduction responsible for the Early Jurassic Cu mineralizations, middle Later Jurassic Farallon Izanagi triple ridge subduction and transfaults subduction resulting in the Middle Jurassic Cu(Mo)(W) mineralizations and subsequently large scales WSn mineralizations in several episodes, the Cretaceous Izanagi plate subduction beneath the South China craton is the source of Cretaceous porphyry Cu, W and Sn mineralizations.