There have long been controversies with the precise time of the QinghaiTibetan Plateau uplifting, and the dating data are 45Ma, 32Ma and 14Ma, respectively. This paper takes the Ke Kexili Basin——he largest red basin in the hinterland of the QinghaiTibet Plateau as an example to study the time of the the QinghaiTibetan Plateau lifting, its features and effects in terms of sediments, biology and volcanic rocks since the PaleoceneMiocene. Our study indicates that there was a decreasing event in temperature occurring at the plateau in the PaleoceneMiocene. The composition is characterized by calcilutite and adakitic rock; the organism by phytolith composing mainly of gymnosperm. The QinghaiTibet Plateau was being lifted since the Middle Miocene