The granite- hosted uranium deposits in South China are spatially associated with U- rich granites (U＞10×10-6). Understanding the petrogenesis of these uranium- bearing granites, with high U contents, is significant not only for formulating exploration strategies but also for gaining better insights into the mechanisms of U enrichment and mineralization. Here, we investigate the Xiazhuang granites,a representative suite of U- bearing granites with high U contents, using zircon U- Pb dating, zircon trace elementanalysis, and biotite and chlorite geochemistry to constrain their petrogenesis and relationship with uranium mineralization. LA- ICP- MS zircon U- Pb dating shows that the Xiazhuang granites were emplaced between 236 and 234 Ma. Their parental magmas were derived from the partial melting of F- rich Paleoproterozoic metasedimentary rocks and subsequently underwent a relatively high degree of magmatic differentiation. During magmatic evolution,oxygen fugacity decreased while U contents increased, leading to the formation of U- rich granites (U＞10×10-6) containing abundant U- rich accessory minerals such as uraninite, monazite, xenotime, and thorite. Our study suggests that these primary U- rich accessory minerals were later altered by hydrothermal fluids under relatively acidic and oxidizing conditions,likely in response to Yanshanian mafic magmatism. This alteration facilitated uranium leaching, providing a source for subsequent uranium mineralization.