The continuous interaction between Paleo- Pacific/Pacific plate and Eurasian continent has not only caused strong structural deformation and magmatic activity in the eastern China, but also contributed to lithospheric thinning, decratonization and destruction of the ancient and stable eastern North China Craton (NCC) in the Mesozoic, and induced continuous crustal extension and thinning following the destruction. In this study, we have conducted study on the cooling and exhumation history of the southern Liaodong Peninsula using various low- temperature thermochronologic methods, including zircon and apatite (U- Th)/He dating and fission track analyses, combined with zircon and apatite U- Pb ages, in order to understand the history and mechanism of the continuous crustal extension and thinning after the destruction of the NCC. The apatite fission track (AFT) and apatite/zircon (U- Th)/He data of the five granitic samples collected from the southern Liaodong Peninsula and AFT thermal modeling for four representative samples unraveled that the southern Liaodong Peninsula experienced three stages of rapid cooling and exhumation during ~ 120～95 Ma, 85～70 Ma and 55～40 Ma, which well correspond to the three stages of extensional deformation occurred in the NCC as well as eastern China since the Late Mesozoic, this may be attributed to the lithospheric thinning and destruction of the eastern NCC, and continuous multi- stage crustal extension and episodic thinning following the destruction, triggered by the continuous episodic retreating subduction of the Paleo- Pacific/Pacific plate towards Eurasian continent and subsequent mantle upwelling since the Late Mesozoic.