Selin Co, located at the transitional region of Indian monsoon and westerlies circulation in the central QinghaiTibetan Plateau (QTP) and controlled by both, is an ideal place for studying the change characteristics of their advanceretreat history. Based on the abundance and trace elements (Mg/Ca and Mn/Ca) in shells of Limnocythere inopinata, we reconstructed the paleoclimate changes since 5.3 ka BP in Selin Co. 5.3~2.9 ka BP, the low abundance and decreased Mg/Ca ratios in shells of L. inopinata indicated cold and humid climate. 2.9~1.8 ka BP, the temperature rose slightly implied by the increase of abundance and little rise in Mg/Ca ratio of L. inopinata, but the reduced Mn/Ca ratios indicated that the lake levels kept decrease compared with the previous stage. The abundance of L. inopinata reached the maximum since 1.8 ka BP, the high values of Mg/Ca and Mn/Ca ratios showed the significant increase of temperature and lake levels. Comparing with the sedimentary records of other lakes in westerlies region, transition region and Indian monsoon region, we think that the central QTP was affected by westerlies circulation in the late stage of Middle Holocene, the temperature was low, but the abundant moisture brought by the westerlies made the lake expand, while in the Late Holocene, the westerlies circulation gradually withdrew northward and Selin Co was more affected by the Indian monsoon, the increased lake water level of Selin Co was closely related to the increase in precipitation and glacialmelt water caused by the rise of temperature under the enhancing of the Indian monsoon.