The mineralization of Himalayan leucogranite in the newly identified rare- metal metallogenic belt, including the proven large deposit as Cuonadong, is dominated by the Be- Nb- Ta (Sn- W) assemblage. Although the spodumene- bearing pegmatite occurred in a few outcrops, so far no industrial lithium deposit has been found. The analysis and comparison of the characteristics, conditions and possible potential of Himalayan pegmatite mineralization (especially Be/Li) with other pegmatite rare element ore belts in China will promote the discovery of Himalayan pegmatite deposits, especially lithium deposits. The parental leucogranites are similar to the rare metal mineralized granite from South China, showing a highly fractionated but narrow evolution span and high melt Li concentration. In the Indo- Asian continental collision zone, the complex tectonic- metamorphic- anatectic process caused multi- period magmatic activity, especially the massive magma during the Neo- Himalayan period can provide favorable heat and material for the formation of pegmatitic melts, long- distance migration and differentiation, and mineralization. Based on the characteristics of Li- bearing pegmatites formed in the distant parental granite and high altitude, we propose that the upper part of the regional tectonic horizon or higher altitude spots and the surrounding rocks at the distal end of the leucogranite may be the suitable emplacement space and the key prospecting area of Li- bearing pegmatite.