The Weilasituo orefield is a typical hydrothermal vein type tin polymetallic orefield in the southern Great Xingan Range. Metallogenic geological characteristics show that the deep concealed alkali feldspar granite is its causative magma with significant spatial dependence between them, showing obvious mineralization and alteration zoning. The metallogenic center is W- Sn- Li- Rb mineralization, which is mostly accompanied by greisenization and silicification, and the distal end is Cu- Pb- Zn- Ag mineralization, with strong limonitization and fluoritization， which forms a relatively complete magmatic- hydrothermal tin polymetallic metallogenic system. Geochemical characteristics indicate that the zoning is clear. W, Sn, Mo and Bi are located in the center of the anomaly, while Cu, Zn, Pb, Ag, As and Sb are located outside the anomaly. The characteristics of natural heavy sand indicate that heavy sand minerals also show obvious zoning. There are more cassiterite heavy sand particles in the center of the orefield, and the mineral assemblage is cassiterite+sphalerite+pyrite. The cassiterite in the outer sulfide mineralization area is less, and the heavy sand mineral assemblage is chalcopyrite+sphalerite+galena+pyrite. Geophysical characteristics show that the Sn- W polymetallic deposit in the metallogenic center corresponds to low gravity, medium and low polarizability, medium and high resistivity and low magnetism measured by geophysical prospecting, and slightly higher IP anomaly appears locally. The characteristics of high gravity, high polarizability, low resistivity and high magnetism in geophysical prospecting survey corresponding to peripheral lead, zinc and silver. Based on the geological, geophysical and geochemical characteristics of the Weilasituo orefield, a comprehensive model for prospecting and exploration of tin polymetallic deposits is established.