A reliable chronostratigraphic framework is crucial for better understanding the evolution history of paleoenvironment，neotectonics, and climate change in the North China Plain (NCP). In this study, we established a high- resolution chronostratigraphic framework for the SFQ1 borehole located in the east of Jizhong depression, NCP, and discussed its far- reaching geological significance. In the SFQ1 borehole, the Mid/Lower Pleistocene boundary (0. 78 Ma) is placed at 71. 0 m depth, the Pliocene/Pleistocene boundary (2. 58 Ma) at 197. 8 m depth, and the Gilbert/Gauss boundary (3. 58 Ma) at 328. 7 m depth. The borehole bottom is dated to around 4. 74 Ma. Borehole joint sections, across different structural units revealed that the depressions in NCP were rapidly filled up and the NCP had become relatively flat at the beginning of the Quaternary, due to the tectonic uplift effect of the Tibetan Plateau during 3. 6~3. 0 Ma. Nevertheless, because of the inherited development of neotectonic movement, the study results revealed that the depth of the bottom of the Quaternary shows obvious differences. As the tectonic movement and sedimentary structure of the NCP had a restrictive effect on hydrogeological conditions since late Pliocene, we suggest that Quaternary research should be strengthened during hydrogeological survey in NCP to improve the accuracy of water resources evaluation.