Seafloor hydrothermal system is an important component of the earths heat balance, and is also the main site of geochemical cycling and mineralization, which has strong spatial relationship with the mid- ocean ridge system. The hydrothermal deposits developed in the slow- and ultraslow- spreading mid- ocean ridges have the characteristics of high distribution density and large mineral resource, among which the number of active hydrothermal vents confirmed accounts for about one third of the total number of the world. The development of hydrothermal massive sulfide deposits is controlled by magmatism and tectonic background, in which the tectonic setting includes non- transform discontinuities and detachment fault system, and the hydrothermal deposits controlled by tectonic setting have higher metal grade and larger deposit area. The study found that the grow of detachment fault has strong connection with the heat source and metallogenic location of hydrothermal activity in space and time. As the oceanic core complex matures, the heat source moves from the ridge axis to the footwall, and the hydrothermal metallogenic position changes from the central valley to the termination and then transfers to the crest of the oceanic core complex. At the same time, the lithologic differences of host rocks also have certain constraints on the types and concentrations of hydrothermal massive sulfide metals. To find out the coupling relationship between hydrothermal mineralization location and lithology and tectonic activity is of great significance for studying the evolution process of hydrothermal activity and prospecting.