For a long time, there has been a lack of accurateconstraint on the magmatic activity and tectonic evolution in the western Ethiopia. Thus, we selected the granite in the Bure area, western Ethiopia, and carried out zircon U- Pb dating and whole- rock geochemicalanalysis. The results show that the LA- ICP- MS zircon U- Pb age of the Bure granite is 733. 8±8. 1 Ma, which is the product of Neoproterozoic magmatic activity. The high SiO2 (72. 26%~72. 78%) and Al2O3 (14. 91%~15. 82%), low MgO and relatively low Na2O/K2O ratio (1. 13~1. 38), high Sr (310×10 -6~401×10 -6), Sr/Y (64. 9~113. 6), La/Yb (25. 7~51. 6) and low HREE, Y (2. 71×10 -6~4. 78×10 -6) and Yb (0. 20×10 -6~0. 31×10 -6) and (La/Yb)N (18. 4~37. 0; <50) of Bure granite show the characteristics of adakite, which is mainly formed by the partial melting of the thickened lower crust. TheBure area of western Ethiopia was in the main collision stage of East African orogeny at 750~710 Ma, resulting inthe partial melting of the thick newborn lower crust by the arc- continent (continent- continent) collision.