The Central African Copper belt is a key copper production area and the largest cobalt production area in the world. The Zambian Copper belt is part of the Central African Copper belt and more than 90% Cu resources are contained in the sedimentary deposits from the Copper belt province of Zambia. This study focuses on Mwambashi Cu deposit, Chambishi West Cu orebody, and Chambishi Southeast Cu- Co orebody in the Chambishi basin in the middle of the Copper belt province of Zambia, conducting researches on petrography, major and trace elements, rare earth elements for the ore- bearing strata. It aims to analyze the provenance and tectonic settings, and investigate Cu- Co metallogenic geological background. The petrography research shows that the main ore- bearing strata include sandstones in the Mindola Formation, and shales, fine- grain sandstones, slates, quartzite, etc. in the Kitwe Formation. The REE patterns are characterized by LREE enrichment and flat HREE features, showing negative Eu anomalies. ICV (Index of Compositional Variability) and CIA (chemical index of alteration) values indicate the sedimentary source does not experience strong sediment recycling and chemical weathering. For the Mwambashi deposit, Chambishi West orebody, Chambishi Southeast orebody, there is a trend from the warm and wet environment to the cold and dry environment. Lithogeochemical plots indicate the provenance for the ore- bearing strata are mainly felsic sedimentary and igneous rocks, which dominantly form in the tectonic settings of passive margin, followed by the settings of positive marginand continental island arc. It is likely the ore- bearing Kitwe Formation is mainly formed in the continental arc setting with added mafic components.Based on the regional geochronology of the Cu- Co sulfides, it is suggested that there are multi- stages for the Cu- Co mineralization in the Central Africa Copper belt. The strata provenance, redox condition in the diagenetic stage, and regional tectonic events finally result in Cu- Co metallogenic differences in the Zambian Copper belt.