The Central African Copper Cobalt Belt is one of the largest and the most economically viable sediment- hosted stratiform Copper belt. The formation and distribution of Cu- Co deposits was controlled by the regional sedimentary rocks and tectonics, and the mineralization has multistage characteristics. A large number of pre- folding, disseminated and bedding, parallel vein- hosted mineralization indicates that there might be a superposition of mineralization after the diagenesis prior to the orogenic tectonic deformation.By using the whole rock Rb- Sr dating and Sr- Nd isotopic tracing,this paper obtained anisochronal age of 742±32Ma (MSWD=0. 39) of the early disseminated mineralized black shale, which is the same age as the Mwashya- Nguba rifting. The late veined mineralized black shale and the internal isochronous line constituted with the dolomite and chalcopyite in the veins yields ages of 680±24Ma (MSWD=0.95) and 678±21Ma (MSWD=1. 5) respectively, which are consistent with the early stage of subduction orogeny caused by Congo- Karahari Craton convergence. Based on the Sr and Nd isotopic characteristics, it is suggested that orematerial in the early disseminated mineralization came from felsic basement and contemporaneous mafic volcanic rocks. However, the metal inthe late vein- hosted mineralization was derived from mafic basement and host rocks, and related to the mineralization of circulating hot brines in the basin.Moreover, field evidence indicates that bedding parallelling vein- hosted mineralization and its associated transgressive veins, and brecciated mineralization with the three- dimensional connectivity are the products of contemporaneous mineralization. These veins weregenetically related to the hydraulic fracturing and lateral excursion of overpressured fluids caused by regional compression that was driven by subduction orogeny. In such context, the end of Rodinia breakup and the beginning of Gondwana assembly around 700Ma resulted in the transformation of regional tectonic regime from extension to compression, which might be the geodynamic mechanism of regional large- scale superposition of Cu mineralization.