The thermal lithospheric thickness is an important parameter for studying the structural evolution and plate dynamics of the basin. In this paper, the crustal layering model is constructed from the measured data. Based on the basic principles of heat conduction, the temperature of the Moho surface and the thermal lithospheric thickness in the central Jizhong depression are calculated, and its geothermal significance is discussed. The results show that the temperature of the Moho surface in the central Jizhong depression is 500～600℃, and the overall temperature in the southwest is higher than that in the northeast. The thermal lithospheric thickness is 102～122 km, and its distribution characteristics are similar to that of the North China Craton, which is thick in the west and thin in the east. This distribution provides a basis for the destruction of the eastern part of the North China Craton caused by the westward subduction of the Pacific Plate. The thin lithosphere conducts the heat flow more easily to the shallow crust, which has become the region of the hightemperature thermal anomaly in this area.