During the exploitation of Enhanced Geothermal System (EGS), it is necessary to inject circulating water to complete the heat extraction. However, the reaction between water and hot dry rock (HDR) may cause mineral dissolution (or precipitation), which may destroy the artificial reservoir and affect the development of geothermal energy. In this paper, the dry hot rock in the Matouying district of the Hebei Province is studied together with groundwater, sea water and pure water. A Phreeqc Stimulator is used to analyze the mineral changes of HDR and the chemical composition changes of injection water after the interaction between water and rocks. The research results show that different injection water and HDR will produce different types of mineral dissolution and precipitation. Finally, the precipitation from sea water was lower than that of groundwater, mainly because the sea water reacts with HDR to form zeolite which has adsorption capacity. Correct reduction of the Cl- content in sea water will enhance its benefit as circulating water.