The Shizishan copper deposit in Yimen is one of the typical copper deposit in the Proterozoic Kunyang rift of the Kangdian area. Orebodies in the deposit are obviously controlled by the secondary structure of the northwest wing of the Shizishan anticline. The ore textures mainly include vein, disseminated, massive and a small amount of lamination.In order to determine the age of tectono- hydrothermal mineralization, the porphyrical chalcopyrite and bornite coexisting with quartz and calcite vein are selected for petrographic study, and chalcopyrite and bornite for high- precision Re- Os dating. Three groups of model ages were obtained from early to late: ① 1749±18~1761±18 Ma; ②1358±14~1549±16 Ma; ③ 449. 4±4. 7 Ma. An isochron age of 1538±130 Ma was obtained for the samples in second model ages range. According to the analysis of sulfur isotopic compositions, the ore- forming materials of the copper deposits hosted in the Luoxue Formation mainly come from the crust, and some from the deep earth. Combined with the regional tectonic magmatic events, it is considered that a small- scale magmatic hydrothermal metallogenic event occurred in Paleoproterozoic, forming a small amount of copper sulfides. The Mesoproterozoic is the main metallogenic period of the mining area, which may be related to the strong tectonic thermal event of the piercing structure. The small- scale metallogenic event also occurred in early Paleozoic, which may be related to the response of Caledonian movement in this area.