The Zhilingtou deposit has a “three- story” mode: the upper part (volcanic rock caprock) is dominated by lead- zinc deposits and sulfur deposits, the middle section (metamorphic rock basement) by gold- silver and lead- zinc deposits, and the deep part (intrusive rock) by porphyry molybdenum deposits. Based on the previous studies, this paper determined the ore- forming age of the Zhilingtou deposit by molybdenite Re- Os isotope dating. The model age of the six molybdenite samples was 113. 7~114. 6 Ma, with a weighted average age of 114. 03±1. 78 Ma, indicating that the mineralization of the Zhilingtou Mo polymetallic deposit occurred in the late stages of the Early Cretaceous. The Re content of the molybdenum sample in this deposit changed from 16. 05×10 -6 to 66. 29×10 -6 , indicating that its ore- forming material has the characteristics of crust- mantle mixed source. The sulfur composition of sulphide has a narrow range of changes (-2. 1‰~2. 6‰), which reaches the equilibrium of isotope fractionation and may be derived mainly from the deep magma of the upper mantle or the lower crust. It has a relatively uniform source of sulfur, but may also be affected by the continental crust. The range of lead isotope composition of the ore minerals from the Zhilingtou Mo- Pb- Zn- Au polymetallic deposit is relatively small. The values of 208 Pb/204 Pb , 207 Pb/ 204 Pb, and 206 Pb/ 204 Pb are 38. 765~39. 137, 15. 523~15. 751, 18. 450~18. 667, respectively, indicate crust- mantle mixing characteristics. The determination of the ore- forming age of the Zhilingtou Mo polymetallic deposit provides an important clue for the prospecting of contemporary porphyry ore- forming systems in the region, and provides new information for further studying the petrogensis and metallogeny of the southeast coastal metallogenic belt.