Nanling region is one of the most important fluorite ore- concentrated rich areas in China. In this study, mineralization styles, spatial distribution, geochronology, rare earth element composition, ore- forming fluids and genesis of fluorite deposits in this region are systematically investigated. Fluorite deposits decrease in number from the eastern to the western subzone, and most of the reserves are concentrated in the middle subzone. The middle subzonemainly hosts the associated type mineralization, while the single type fluorite deposits are commonly found in the eastern and western subzones. Their ages range between 160~100 Ma with a peak between 160 Ma to 135 Ma. Deposits in middle subzone are older than that those inthe eastern and western subzones. The single type fluorite deposits have significant time lag between mineralization and its associated granite emplacement (10~20 Ma). They are considered to have crystallized from meteoric waters which constantly leached and enriched fluorine from granite and calcium from strata. The associated type fluorite deposits were primarily produced by magmatic hydrothermal activity.