Abstract:The Zhilingtou deposit has a "three-story" mode, the upper (volcanic rock caprock) is dominated by lead-zinc deposits and sulfur deposits, the middle (metamorphic rock basement) is dominated by gold-silver and lead-zinc deposits, and the deep (intrusive rock) is dominated by porphyry molybdenum deposits. Based on the previous studies, this paper determined the ore-forming age of the Zhilingtou deposit through the molybdenite Re-Os isotope dating. The model age of the six molybdenite samples was 113.7~114.6 Ma, and the weighted average age was 114.03±1.78 Ma, indicating that the mineralization of the Zhilingtou Mo polymetallic deposit occurred in the late stages of the Early Cretaceous. The Re content of the molybdenum sample in this deposit changed from 16.05 to 66.29 μg/g, indicating that its ore-forming material has the characteristics of crust-mantle mixed source. The sulfur composition of sulphide has a narrow range of changes (-2.1‰~2.6‰), which reaches the equilibrium of isotope fractionation. It may be mainly from the deep magma of the upper mantle or the lower crust. It has a relatively uniform source of sulfur, but may also be affected by continental crust. The range of lead isotope composition of the ore minerals from Zhilingtou Mo-Pb-Zn-Au polymetallic deposit is relatively small. The values of 208Pb/204Pb, 207Pb/204Pb, and 206Pb/204Pb are 38.765~39.137, 15.523~15.751, 18.450~18.667, respectively, which has obvious crust-mantle mixing characteristics. The determination of the ore-forming age of the Zhilingtou Mo polymetallic deposit provides an important clue for the prospecting of contemporary porphyry ore-forming systems in the region, and also highlights new information and evidence for further studying on the petrogensis and metallogeny of the Southeast coastal metallogenic belt.