Through the integrated study on the Plate activity and the structural system in the South China continental region since Meso- Neoproterozoic, this paper deals with the genetic relation between the structural system and the Plate activity in aspects of deformation features of the structural system, evolution history and formation mechanism.Therefore, the multi- system composite structural framework dominated by the Yangtze inverse s- type structural system, Neocathaysian structural system and Nanling latitudinal belt has been proposed. Among them, the newly- cognized the Yangtze inverse s- type structural system is the major structure of the Yangtze Plate. It originally belonged to the Cathaysian structural system, was established by Neoproterozoic continental collision between the Yangtze Plate and the Cathaysian Plate,and completed durin the Yanshanian intracontinental orogeny. Meanwhile, the Neocathaysian structural system belongs to the major structure in the marginal west- Pacific and includes genetically related NE- Cathaysian and NNE Neocathaysian, with the genetic relation, both of them underwent the evolution processes of the Yanshanian compressional shear assembly, post- orogenic extension and the weak compressional since the Quaternary period. The well- known Nanling latitudinal zone mainly formed as a result of the Yanshanian meridional compression is characterized by the EW- trending superimposed fold- granite belt, and continues until now. Finally, this paper also describes the major structural system metallogenetic belts within the composite controlling district, the characteristics of the grading stepping controlling ore concentration districts, ore fields and deposits,as well as the core- mantle- style expansion model for magmatic metallogenic explosion of the Yanshanian. It is concluded that the Yanshanian intracontinental activization orogenesis within the region shew, the multi- direction convergent and the multi- factor recombination dynamic features predominated by the nearly SN- trending sinistral shear between the Eurasian Plate and the Pacific Plate.