Hyperspectral remote sensing techonogy, as the frontier and hot topic in the field of remote sensing geology, is gradually generalized in oil and gas exploration, but it hasn’t gotten good effect because of complex interferences on ground surface, it is difficult to distinguish the real information. Hyperspectal remote sensing data with high spatial and spectral resolution have been collected in Junnggar Basin and Yili Basin,Xinjiang, using the CASI/SASI/TASI airborne hyperspectral imaging system. This study was supported by the project “Oil and gas resources survey”of Oil and Gas Resource Center,CGS. By means of establishing the spectral model of oil- gas seepage and comparing the spectra curves of oil- gas seepage and interferences, and the relationship between hydrocarbon and alteration minerals to solve the problem of eliminating the interferences when extracting the oil- gas seepage information. Meanwhile, one mapping method suited to oil and gas information extracting has been developed, it emphasizes that oil and gas geology knowledge should be run through the whole process of extracting, so it significantly improves the effect of oil- gas exploration using airborne hyperspectral remote sensing. Demonstration application indicates that it can extract oil and gas information with higher efficiency, and distinguish oil bearing formation and non- oil bearing formation. Furthermore, oil shale and oil bearing coal bed can be extracted, and the distribution characteristics and controlling factors also can be observed directly. Besides, it can extract anomaly information of oil gas seepage, especially in the quaternary coverage area, and delineate the anomaly area of oil gas seepage. Those effects described above are important information for oil and gas resources survey, favorable area selection and evaluation.The technical advantage of oil gas exploration using airborne hyperspectral remote sensing which can’t be replaced by other methods can play an important role in oil gas resources survey and exploration.