Copper polymetallic mining area in Duolong, Tibet, is endowed by abundant mineral resources with a reserves of about 25 million tons, ranking the first in China. Mineral development in this ore cluster area will not only bring significant benefit for society and economy, but also cause irreversible damage to the ecological environment due to its limited bearing capacity. To understand the current situation of ecological environment, we extracted the related ecological environment information, such as social activities, hydrology, desertification, metal oxide, vegetation cover, and so on, from the dataset of GF2 and Landsat 8. Analytical results show that the ecological environment in the study area is generally in a primitive state and untouched by largesized industrial and human activities; the plateau grasslands and plateau meadows are the main vegetation types distributed in relatively small areas. But the problem facing this area is severe desertification including desertification, desertification and salinization, etc. Largecale ferritization and malachitization occur in the mining area, around which soils and waters contain high contents of metals and heavy metals. But human activities in the mining area, such as illegal mining for placer gold, overload herds, and geological survey, all cause a certain influence on the local ecological environment. RS and GISbased investigation of the geological and ecological environment in the Duolong ore cluster area can provide some suggestion and technical support for location and construction of environmentally friendly mining.