Here we report for the first time discovery of an unusual mineral group in the harzburgites of the Xigaze ophiolite, which lies in the middle section of the Yarlung-Zangbo suture. The mineral features are similar to those found in mantle peridotites in the eastern and western sectioins of the Yarlung-Zangbo suture. The Xigaze ophiolite consists mainly of harzburgite, and minor lherzolite and dunite, with pyroxenite and gabbro dikes cutting the harzburgite. More than thirty unusual minerals were obtained by standard mineral separation techniques from a 465 kg of harzburgite sample, including native elements such as diamond, gold, chrome, copper; carbide such as moissanite; oxides such as wustite, hematite, magnetite, corundum, spinel, cassiterite, wolframite; sulfides such as pentlandite, galena, stibnite, molybdenite, sphalerite and arsenopyrite; Ag-Au alloy minerals; silicates, tungstates and fluoride. The presence of diamond, native Au, Cr, and Cu, together with moissanite, indicates a strong reducing environment. The set of unusual mineral assemblages indicate that the Xigaze ophiolite as other ophiloites in this suture may have experienced deep mantle evolution.