Weijing compound granite of Hercynian to Yanshanian periods, located at the SinoMongolia boundary, belongs to the results of the extension of crust thickening subsequent to closure of the MongolOkhotsk Ocean. Apatite fission track age of the Weijing granite ranges from 767 to 538 Ma. Based upon the thermal simulation, the Weijing granite undergone a rapid uplifting and denudation event during the Late Cretaceous, but was in a very stable lowspeed denudation setting without obvious tectonic event during the whole Cenozoic period. The Late Cretaceous tectonic thermal event which the Weijing granite experienced corresponds to the angular unconformity between the Early and Late Cretaceous in its northern and eastern faulted basins (such as Erlian, Haila’er, and Songliao basins), which represents a tectonic inversion events. Due to the fact that the northern margin of North China Craton (NCC) was affected by the tectonic thermal event, this event might be closely related to the rapid subduction of the Izanagi Plate into the East Asian continent. Combined with low temperature thermal chronology data, the Late Cretaceous tectonic event might influence the west of Weijing granite and east of the Mandula area. Thermal simulation results demonstrate that the Weijing granite denudates at a speed of about 01 to 02 mm/a. Present topography of the eastern part in the northern margin of the North China has taken a shape likely since the Cenozoic, but not during early or middle Mesozoic. Study of uranium mineralization indicates that a largescale mineralization occurred in both mudstones of the upper Cretaceous Erlian Formation and sandstones of the lower Cretaceous Saihan Formation in the Erlian basin. All these uranium mineralization followed uprising event of the western margin of the basin in the late Cretaceous, and uranium in the Ubearing oxide fluid, leached from the Ubearing Weijing granite, migrated continuously into the orebearing mudstones and sandstones. Hence, uplift and denudation of the Weijing granite is an important factor controlling uranium mineralization in the basin and the timing of uplift is basically consistent to uranium mineralization in the Erlian basin.