MesoCenozoic intracontinental orogenic process in the Tianshan orogenic belt has a significant controlling effect on the sandstone type uranium deposits in the intramontane and bilateral basin. This study carried out the systematic analysis of the samples from Sawafuqi uranium deposit using thin section observation, α track radioactive graph technique, electron probe and scanning electron microscope. The results show that the Sawafuqi uranium deposit occur as tabular, lamellar, quasi lamellar, lenslike ore bodies, with high ore grade in the South Tianshan orogenic belt, which is different from typical interlayer oxidation zone sandstonetype uranium deposit. The three mineralization types have been identified in the deposit: preliminary sedimentary mineralization, interlayer oxidation zonetype uranium mineralization, and epithermal veintype uranium mineralization. Three uranium mineralization presents obvious formation sequence, with the preliminary sedimentary uranium mineralization forming early uranium enrichment, interlayer oxidation zone uranium mineralization forming the main orebodies, followed by late superimposed enrichment by the latestage epithermal uranium mineralization. Combined with previous study of the MesoCenozoic orogeny in South Tianshan, it can be concluded that preliminary sedimentary type uranium mineralization of the Sawafuqi uranium deposit was caused by Triassic Tianshan uplifting; interlayer oxidation zonetype uranium mineralization occurred in a relatively stable tectonic setting in the EocenceOligocene period; and since the Miocene, orogenic hydrothermal solution derived from strong folding and orogeny of South Tianshan reformed the former uranium ore bodies, thus resulting in the superimposed enrichment of epithermal veintype uranium mineralization.