Honghaigou deposit is one of the large uranium deposits discovered in the southern margin of the Yili basin in recent years, which hosts not only sandstonetype Ubearing orebodies but also coaltype uranium orebodies. In this paper, we firstly studied the geological characteristics of the Honghaigou deposit, analyzed main controlling factors and then discussed the constraint of structure and sedimentation on the oxidation zone development and uranium spatial orientation. The study suggests that secondary uplifting along structural slope provides driving force for recharge and migration of fluid, with change sites of the slope being favorable for unloading of oreforming minerals. The main sandbody is channel for migration of oxidation fluid, which restricts the direction of the migration of the oxidation fluid. The change of sandbody resulted in pitching out of oxidation zone and spatial distribution of uranium orebodies. The diversity of the oxidized fluid zonation resulted in the diversity of orebody types and morphology, with the planes of interlayer oxidation zone controlling the occurrence of sandstonetype uranium orebodies and the vertical zonation of oxidized fluid controlling the spatial location of the coaltype uranium orebodies.