Asan important component of Derbugan metallogenic belt, Genhe district in Da Hinggan Mountains has significant lead-zinc-silver mineralization and has 3 large deposits, which are Derbur, Erdaohezi and Biliyagu. On the basis of investigation on geological characteristics of deposits in field works, authors have researched geochemical characteristics of rocks and LA-ICP-MS U-Pb ages of zircons in the above ore districts. Research Results show that rhyolitic volcanic rocks in ore districts belong to (high K) calc-alkaline series and andesitic volcanic rocks belong to calc-alkaline series with high K. Both series have significant inheritance and a few differences on some degree, and they should be products of different volcanic cycles under a same magmatism. Eclogite with plagioclase and granulite should be major components of magmatic source. The forming depth of magma was shallow and the forming pressure of magma was low. Only a little depths of magmatism could reach to mantle with facial of eclogite. Combining LA-ICP-MS U-Pb ages of rocks, magmatic sources change from mixture of crust and mantle to mantle with the change from rhyolitic series(159.2±1.8Ma，163.6±1.3Ma) to andesitic series(144~128Ma). However, the study area was located in the eastern part of scissor-type occlusive effect of Okhotsk Ocean during the late period of Middle Jurassic and the early period of Late Jurassic, and so the whole area was in the background of orogenic belt. Lead-zinc-silver deposits formed in a relative extensional environment after the orogenic action.