The Reko Diq porphyry Cu-Au oreconcentrated area is one of the most important producing area for Cu-Au deposits in Pakistan, where occurred more than 20 Cu-Au deposits (occurrences), containing worldclass deposits (such as H14 and H15). On the basis of previous studies, the Pb, Sr and Nd isotopic compositions of these typical deposits have been reanalyzed and rediscussed, and their HH single stage evolution model ages of lead isotope as well as the characteristic parameters of Pb, Sr and Nd isotopes (such as, Th/U ratios, μ, ω, △α, △β, εSr and εNd values) have been calculated in this paper. The study results show that, the oreforming materials are mainly derived from the crustmantle mixing substances that controlled by magmatism, which are caused by the subduction and recycling of Neotethys oceanic lithosphere or the injection of mantlederived magma into crust. Accompanied with the evolution of Tethyan tectonic domain, the orebearing porphyries in the Reko Diq oreconcentrated area may be formed in the evolution process of arc collisionorogenic belt, belonging to the products of crustal accretion and thickening that resulted in the processes of oceanic crust subduction and continental collision. These porphyries have some affinity with the Yangtze block, constituting a part of archipelagic ocean model in Tethyan tectonic domain. For the Reko Diq oreconcentrated area, these leads belong to the mixed leads with radiogenic leads, displaying the DUPAL abnormal characteristics. In which, the abnormal leads may be sourced from the upper crustal materials that enriched U and Th elements, but the DUPAL anomalies may be directly derived from the EMII and DM mixing origin in the southern margin of Eurasian continent and display as the form of anomalous lead.