Based on the study of tectonic deformation features in the QishanLinyou areas in the southwest of Weibei uplift, and combined with fissiontrack analysis as well as thermal evolution simulation, this paper discussed the Mesocenozoic tectonic dynamic thermal evolution and its response in geology. The results show that Yanshan movements were associated with largest impact on tectonic deformation in the study area, and there may be three times of uplift process, which occurred in the end of Jurassic to Early Cretaceous (138~128Ma), Late Cretaceous (86~69Ma) and Eocene (50~40Ma). The spatial distribution of AFT ages suggests that the time of uplift and cooling in the study area is characteristic of early in than in north, was the overall uplift taking place later. The results of the thermal evolution simulation indicate that the southern areas reached largest in palaeogeotherm in 158Ma, and had experienced rapid uplift during the period from 158 to 130 Ma, slow uplift between 130 and 40 Ma, and further rapid uplift after 40 Ma. Corresponding, the Mesocenozoic tectonic thermal evolution in the study areas remained a close contact on adjacent units. The uplift in Late Jurassic tectonic should be relative to the process that the QinQi orogen entered a strong multi cycle intracontinental orogenic period. The early Cretaceous stable subsidence stage was the key period to mature oil and gas in Ordos Basin. The tectonic uplift in the late Cretaceous was consistent with Qinling orogenic belt. The rapid uplift in Eocene was caused by the tilting effect of the northern margin, which was associated with the formation of Weihe Basin.