The volcanogenic claystone, deposited globally, especially around the Tethyan Realm in the Permian Triassic Boundary (PTB), plays a significant role in understanding the triggering mechanism and associated geological events for the Latest Permian Mass Extinction (LPME). Here, we present research of claystones around the PTB on mineralogy, petrology and geochemistry, which has filled the blank in this area. The results show that the components of the PTB claystone are composed mainly of volcanogenic clays (illite, etc.), and phenocryst minerals (such as quartz, calcite, pyrite and magmatic zircon). Their geochemical compositions are characterized with high K2O and low Na2O, relative enrichment in Large ion Lithophile Element (LILE) and depletion in the High Field Strength Element (HFSE). All the features of the PTB claystone mentioned above suggest that the claystones are volcanogenic kalibentonite with protolith being intermediate felsic rhyodacite and source background of arc type magmatism. Compared with other PTB claystones found in other areas in South China, it can be inferred that all the PTB claystones have similar genesis and likely derived from felsic magmas eruption triggered by either continental collisions around paleo Tethys Ocean or subduction of Panthalassic Ocean along eastern margin of the Pangea Continent including South China plate, and characterized by multiple episodes. These intense volcanic activities in a global scale including the volcanism associated with extensive distributions of the PTB claystones may act as key causes responsible for the Latest Permian Mass Extinction