Shimensi tungsten polymetallic deposit is located in mid-segment of Jiulin uplift, Jiangnan terrane, Yangtze block. The mass balance quantitative calculation of alteration zones elements is by Isocon graphic method in this paper. ∑REE, LREE and HREE is enrichment with different degree at the stages of greisenization and sericitization. Such high rich Cd and In proposes the characteristic of magmatic origin. The Y/Ho ratios of greisenization granodiorite and sericitization granodiorite are 22.77~25.64 and 25.35~26.48, respectively. It implicates that HCO3- is rich in alteration fluids of the tow stages. Mass gain and loss rates of Eu are -29% and 1%, respectively. It demonstrates the fluids of greisenization stage is characterized by high temperature and high oxygen fugacity. There was a positive correlation between W and FeO. Low oxygen fugacity is conductive to enrich and precipitate wolfram. The CaO mass gain and loss rate of greisenization granodiorite is -12%, the reduced Ca2+ gets into metallogenic fluid. The combination of Ca2+ and WO42- comes into being Scheelite in metallogenic fluid. Greisenization of granodiorite is a progress of FeO and CO2 decrease, P increase, hydration and decalcification. To some extent, the change is chemical response with WO42- precipitate, by the interaction between metallogenic fluid and granodiorite. Greisenization granodiorite is characterized by microfissure-rich, and it makes for permeating by metallogenic fluidfor a long time. Metallogenic fluidpermeates the exocontact zone for quite a long distance, with the drive of thermo-motive and pressure difference. A large quantity of plagioclases were releasing Ca2+ when alteration occured, it save circulation quantity of Ca2+from metallogenic fluid. So that, stratoid veinlet-disseminated type scheelite body of large and thick continuous formed in the exocontact zone.